Improving survival rates for adolescents and young adults with cancer.
One of the challenges for the adolescent and young adult (AYA) cancer population is the transition of adolescent cancer survivors treated at pediatric institutions to adult-based providers in their young adult years. Unfortunately, most AYA survivors are not enrolled and followed in survivorship programs and are oftentimes treated by primary care physicians who are unfamiliar with AYA cancers and the long-term effects and issues associated with them.
Source: Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults with Cancer, Report of the Adolescent and Young Adult Oncology Progress Review Group. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, National Institutes of Health, National Cancer Institute, LIVESTRONG™ Young Adult Alliance; NIH Pub. 06-6067; 2006.
Adolescents & young adults: issues in transition from active therapy into follow-up care.
Eur J Oncol Nurs. 2009 Jul;13(3):207-12
Authors: Thompson K, Palmer S, Dyson G
The development of services focused on addressing the needs of Adolescent & Young Adult (AYA) cancer patients as they transition from active therapy into follow-up care is an area of growth, development and research across the globe. This is important as much of the empirical literature and service development to date has...
Acute lymphoblastic leukemia in adolescents and young adults.
Hematol Oncol Clin North Am. 2009 Oct;23(5):1033-42, vi
Authors: Ribera JM, Oriol A
Today, long-term survival is achieved in more than 80% of children 1 to 10 years old with acute lymphoblastic leukemia (ALL). However, cure rates for adults and adolescents and young adults (AYA) with ALL remain relatively low, at only 40% to 50%. Age is a continuous prognostic variable in ALL, with no single age at which prognosis deteriorates markedly....
Transitioning childhood cancer survivors to adult-centered healthcare: insights from parents, adolescent, and young adult survivors.
Psychooncology. 2010 Sep;19(9):982-90
Authors: Casillas J, Kahn KL, Doose M, Landier W, Bhatia S, Hernandez J, Zeltzer LK,
To determine Latino adolescent and young adults (AYA) cancer survivors' perceived barriers or facilitators to transition from pediatric to adult-centered survivorship care and to also assess the parents' perspective of care.
PMID:...
Intraspecific competition between co-infecting parasite strains enhances host survival in African trypanosomes.
Ecology. 2009 Dec;90(12):3367-78
Authors: Balmer O, Stearns SC, Schötzau A, Brun R
It is becoming increasingly clear that under natural conditions parasitic infections commonly consist of co-infections with multiple conspecific strains. Multiple-strain infections lead to intraspecific interactions and may have important ecological and evolutionary effects on both hosts and parasites....
Psychological outcomes and health beliefs in adolescent and young adult survivors of childhood cancer and controls.
J Clin Oncol. 2010 Apr 20;28(12):2002-7
Authors: Kazak AE, Derosa BW, Schwartz LA, Hobbie W, Carlson C, Ittenbach RF, Mao JJ, Ginsberg JP
PURPOSE The purpose of this study was to compare adolescent and young adult (AYA) pediatric cancer survivors and peers without a history of serious...
Recruitment of adolescents and young adults to cancer clinical trials--international comparisons, barriers, and implications.
Semin Oncol. 2010 Apr;37(2):e1-8
Authors: Fern LA, Whelan JS
The last 30 years have seen significant improvements in survival rates for children and older adults. In contrast, the 5-year survival rate among 20 to 39 year olds has been static at around 70% since 1986. Data from the United States, Australia, Italy, and the United Kingdom suggest that this age group also has...
Socioeconomic Impacts on Survival Differ by Race/Ethnicity among Adolescents and Young Adults with Non-Hodgkin's Lymphoma.
J Cancer Epidemiol. 2010;2010:824691
Authors: Kent EE, Morris RA, Largent JA, Ziogas A, Sender LS, Anton-Culver H
Shorter survival has been associated with low socioeconomic status (SES) among elderly non-Hodgkin's lymphoma (NHL) patients; however it remains unknown whether the same...
Clinical and molecular features of papillary thyroid cancer in adolescents and young adults.
Cancer. 2011 Jan 15;117(2):259-67
Authors: Vriens MR, Moses W, Weng J, Peng M, Griffin A, Bleyer A, Pollock BH, Indelicato DJ, Hwang J, Kebebew E
Age disparities in thyroid cancer incidence and outcome among adolescents and young adults (AYAs) with thyroid cancer are under reported. In this study, the authors compared the molecular and clinical features of papillary thyroid cancer (PTC) in AYAs with the...
Music's relevance for adolescents and young adults with cancer: a constructivist research approach.
Support Care Cancer. 2011 Feb 11;
Authors: O'Callaghan C, Barry P, Thompson K
PURPOSE: Music is one of the most widely used activities amongst young people, significant in personal and group identity, motivation, physical release, and emotional support. Adolescents and young adults with cancer (AYA) require specialized care because of intensified challenges related to developmental vulnerability,...
Usefulness of the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) in predicting outcomes for adolescents and young adults with hematologic malignancies undergoing allogeneic stem cell transplant.
Pediatr Blood Cancer. 2011 Sep;57(3):499-505
Authors: Wood W, Deal A, Whitley J, Sharf A, Serody J, Gabriel D, Shea T
The HCT-CI helps to predict non-relapse mortality (NRM) and overall survival (OS) in allogeneic hematopoietic cell transplantation (HCT) recipients. The usefulness of...
Malignant hematologic diseases in adolescents and young adults.
Blood. 2011 Jun 2;117(22):5803-15
Authors: Wood WA, Lee SJ
Adolescents and young adults (AYA) with cancer have been designated as a vulnerable population by the National Cancer Institute. This group, defined by the ages of 16-39 years, has not enjoyed the same survival improvements over the past several decades as older and younger cohorts. Several barriers prevent the optimal delivery of oncologic care in this subpopulation. This...
Unique characteristics of adolescent and young adult acute lymphoblastic leukemia, breast cancer, and colon cancer.
J Natl Cancer Inst. 2011 Apr 20;103(8):628-35
Authors: Tricoli JV, Seibel NL, Blair DG, Albritton K, Hayes-Lattin B
Each year in the United States, nearly 70 000 individuals between the ages of 15 and 40 years are diagnosed with cancer. Although overall cancer survival rates among pediatric and older adult patients have increased in recent decades, there has been little improvement in...
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