Improving survival rates for adolescents and young adults with cancer.
One of the challenges for the adolescent and young adult (AYA) cancer population is the transition of adolescent cancer survivors treated at pediatric institutions to adult-based providers in their young adult years. Unfortunately, most AYA survivors are not enrolled and followed in survivorship programs and are oftentimes treated by primary care physicians who are unfamiliar with AYA cancers and the long-term effects and issues associated with them.
Source: Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults with Cancer, Report of the Adolescent and Young Adult Oncology Progress Review Group. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, National Institutes of Health, National Cancer Institute, LIVESTRONG™ Young Adult Alliance; NIH Pub. 06-6067; 2006.
Surveillance and survival among adolescents and young adults with cancer in Ontario, Canada.
Int J Cancer. 2012 Mar 7;
Authors: Furlong W, Rae C, Greenberg ML, Barr RD
Abstract
Gains in survival rates among adolescents and young adults (AYA) are reported from the USA to be lower than in both younger and older patients. Limiting factors include low accrual to clinical trials related to the type of institutional care. This study aimed to determine the incidence of cancer in the 15-29...
Improved clinical trial enrollment in adolescent and young adult (AYA) oncology patients after the establishment of an AYA oncology program uniting pediatric and medical oncology divisions.
Cancer. 2011 Dec 27;
Authors: Shaw PH, Boyiadzis M, Tawbi H, Welsh A, Kemerer A, Davidson NE, Kim Ritchey A
Abstract
BACKGROUND: Since 1975, there has been a dramatic increase in the survival rates of pediatric and older cancer patients, but adolescent and young adult (AYA) patients ages 15 to 40...
Antitumor effects of YM155, a novel survivin suppressant, against human aggressive non-Hodgkin lymphoma.
Leuk Res. 2011 Jun;35(6):787-92
Authors: Kita A, Nakahara T, Yamanaka K, Nakano K, Nakata M, Mori M, Kaneko N, Koutoku H, Izumisawa N, Sasamata M
Abstract
YM155, a novel small-molecule that down-regulates survivin, exhibits broad, potent antitumor activity against a range of human tumors. We evaluated the activity of YM155 in aggressive non-Hodgkin lymphoma. In a number of diffuse...
End of life care in adolescents and young adults with cancer: Experience of the adolescent unit of the Institut Gustave Roussy.
Eur J Cancer. 2011 Nov 2;
Authors: Cohen-Gogo S, Marioni G, Laurent S, Gaspar N, Semeraro M, Gabolde M, Dufour C, Valteau-Couanet D, Brugières L
Abstract
BACKGROUND: Cancer is the third leading cause of death in adolescents and young adults (AYA). Little is known, however, about how end-of-life unfolds for those who die of progressive disease. In order to...
A social-ecological model of readiness for transition to adult-oriented care for adolescents and young adults with chronic health conditions.
Child Care Health Dev. 2011 Nov;37(6):883-95
Authors: Schwartz LA, Tuchman LK, Hobbie WL, Ginsberg JP
Abstract
Background Policy and research related to transition to adult care for adolescents and young adults (AYAs) has focused primarily on patient age, disease skills and knowledge. Objective In an effort to broaden conceptualization of...
Clinical Trial Participation and Time to Treatment Among Adolescents and Young Adults With Cancer: Does Age at Diagnosis or Insurance Make a Difference?
J Clin Oncol. 2011 Sep 19;
Authors: Parsons HM, Harlan LC, Seibel NL, Stevens JL, Keegan TH
Abstract
PURPOSEBecause adolescent and young adult (AYA) patients with cancer have experienced variable improvement in survival over the past two decades, enhancing the quality and timeliness of cancer care in this population has emerged as a...
Building the bridge between rhabdomyosarcoma in children, adolescents and young adults: The road ahead.
Crit Rev Oncol Hematol. 2011 Jul 28;
Authors: Van Gaal JC, De Bont ES, Kaal SE, Versleijen-Jonkers Y, van der Graaf WT
Rhabdomyosarcoma (RMS) is a rare type of soft tissue sarcoma that mainly affects children, but also occurs in adolescents and (young) adults (AYA). Despite dramatic survival improvements reported by international study groups in children over the past decades, the awareness of a...
Active therapy and models of care for adolescents and young adults with cancer.
Cancer. 2011 May 15;117(10 Suppl):2316-22
Authors: Ramphal R, Meyer R, Schacter B, Rogers P, Pinkerton R
The reduction in the cancer mortality rate in adolescents and young adults (AYA) with cancer has lagged behind the reduction noted in children and older adults. Studies investigating reasons for this are limited but causes appear to be multifactorial. Host factors such as developmental stage, compliance, and...
Usefulness of the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) in predicting outcomes for adolescents and young adults with hematologic malignancies undergoing allogeneic stem cell transplant.
Pediatr Blood Cancer. 2011 Sep;57(3):499-505
Authors: Wood W, Deal A, Whitley J, Sharf A, Serody J, Gabriel D, Shea T
The HCT-CI helps to predict non-relapse mortality (NRM) and overall survival (OS) in allogeneic hematopoietic cell transplantation (HCT) recipients. The usefulness of...
Music's relevance for adolescents and young adults with cancer: a constructivist research approach.
Support Care Cancer. 2011 Feb 11;
Authors: O'Callaghan C, Barry P, Thompson K
PURPOSE: Music is one of the most widely used activities amongst young people, significant in personal and group identity, motivation, physical release, and emotional support. Adolescents and young adults with cancer (AYA) require specialized care because of intensified challenges related to developmental vulnerability,...
Clinical and molecular features of papillary thyroid cancer in adolescents and young adults.
Cancer. 2011 Jan 15;117(2):259-67
Authors: Vriens MR, Moses W, Weng J, Peng M, Griffin A, Bleyer A, Pollock BH, Indelicato DJ, Hwang J, Kebebew E
Age disparities in thyroid cancer incidence and outcome among adolescents and young adults (AYAs) with thyroid cancer are under reported. In this study, the authors compared the molecular and clinical features of papillary thyroid cancer (PTC) in AYAs with the...
Recruitment of adolescents and young adults to cancer clinical trials--international comparisons, barriers, and implications.
Semin Oncol. 2010 Apr;37(2):e1-8
Authors: Fern LA, Whelan JS
The last 30 years have seen significant improvements in survival rates for children and older adults. In contrast, the 5-year survival rate among 20 to 39 year olds has been static at around 70% since 1986. Data from the United States, Australia, Italy, and the United Kingdom suggest that this age group also has...
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