A chief concern affecting quality of life among young adult (YA) cancer survivors is fertility. Although discussions regarding the possibility of infertility and methods to decrease the risk are crucial at the time of diagnosis, many YAs don’t remember having adequate discussions regarding these topics before the initiation of their treatment. Embryo cryopreservation in women and sperm cryopreservation in men before cancer therapy remains to be the most effective ways in which fertility is preserved in the YA population. Although female and male gonadal tissue cryopreservation and transplantation remain experimental, such options are explored and continuously researched through programs such as the Oncofertility Consortium at Northwestern University.
Sources: Levine J, Canada A, Stern C. Fertility Preservation in Adolescents and Young Adults With Cancer. J Clin Oncol. 2010; 28:4831-4841.
Bleyer A, Barr R. Cancer in Young Adults 20 to 39 Years of Age: Overview. Semin Oncol. 2009; 36:194-206.
Inhibition of arachidonate 15-lipoxygenase prevents 4-hydroxynonenal-induced protein damage in male germ cells†.
Biol Reprod. 2017 Feb 02;:
Authors: Bromfield EG, Mihalas BP, Dun MD, Aitken RJ, McLaughlin EA, Walters JL, Nixon B
Testicular Tissue Cryopreservation and Ethical Considerations: A Scoping Review.
J Bioeth Inq. 2017 Mar 28;:
Authors: Petropanagos A
Testicular tissue cryopreservation (TTCP) aims to preserve the future option of genetic reproduction for prepubescent cancer...
Recent advances in the field of ovarian tissue cryopreservation and opportunities for research.
J Assist Reprod Genet. 2017 Apr 01;:
Authors: Ladanyi C, Mor A, Christianson MS, Dhillon N, Segars JH
PURPOSE: The purpose of this study was to summarize the latest...
Premature Ovarian Insufficiency in Childhood Cancer Survivors: A Report from the St. Jude Lifetime Cohort.
J Clin Endocrinol Metab. 2017 Mar 24;:
Authors: Chemaitilly W, Li Z, Krasin MJ, Brooke RJ, Wilson CL, Green DM, Klosky JL, Barnes N, Clark KL, Farr JB, Fernandez-...
[Fertility-sparing management of endometrial cancer and atypical hyperplasia].
Gynecol Obstet Fertil Senol. 2017 Feb;45(2):112-118
Authors: Gonthier C, Trefoux-Bourdet A, Luton D, Koskas M
The fertility sparing management of endometrial...
A Call for Fertility Preservation Coverage for Breast Cancer Patients: The Cost of Consistency.
J Natl Cancer Inst. 2017 May 01;109(5):
Authors: Walter JR, Xu S, Woodruff TK
In 1998, the passage of the Women's Health and Cancer Rights...
Long-acting recombinant FSH in random start ovarian stimulation protocols for fertility preservation in women with cancer.
Acta Obstet Gynecol Scand. 2017 Apr 06;:
Authors: Sarais V, Paffoni A, Pagliardini L, Filippi F, Martinelli F, Mangili G, Candiani M, Papaleo E
INTRODUCTION: The objective of this study was to...
Female patients with lymphoma demonstrate diminished ovarian reserve even before initiation of chemotherapy when compared with healthy controls and patients with other malignancies.
J Assist Reprod Genet. 2016 May;33(5):657-62
Authors: Lekovich J, Lobel AL, Stewart JD, Pereira N, Kligman I,...
The importance of actively involving partners in oncofertility discussions.
Future Oncol. 2016 Jul;12(14):1679-82
Authors: Badr H
PMID: 26952959 [PubMed - indexed for MEDLINE]
Combating radiation therapy-induced damage to the ovarian environment.
Future Oncol. 2016 Jul;12(14):1687-90
Authors: Duncan FE, Kimler BF, Briley SM
PMID: 27117319 [PubMed - indexed for MEDLINE]
Fertility and Early Pregnancy Outcomes Following Conservative Treatment for Cervical Intraepithelial Neoplasia and Early Cervical Cancer.
JAMA Oncol. 2016 Nov 01;2(11):1496-1498
Authors: Kyrgiou M, Mitra A, Paraskevaidis E
Considerations for the Treatment of Young Patients with Breast Cancer.
Breast J. 2016 Nov;22(6):667-672
Authors: Menen RS, Hunt KK
Breast cancer in the young patient, generally defined as younger than 40 years, is a rare but important problem. In the US, over 24,000...
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