A chief concern affecting quality of life among young adult (YA) cancer survivors is fertility. Although discussions regarding the possibility of infertility and methods to decrease the risk are crucial at the time of diagnosis, many YAs don’t remember having adequate discussions regarding these topics before the initiation of their treatment. Embryo cryopreservation in women and sperm cryopreservation in men before cancer therapy remains to be the most effective ways in which fertility is preserved in the YA population. Although female and male gonadal tissue cryopreservation and transplantation remain experimental, such options are explored and continuously researched through programs such as the Oncofertility Consortium at Northwestern University.
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Outcomes of conservative surgery in early epithelial ovarian carcinoma.
Eur J Gynaecol Oncol. 2012;33(1):93-5
Authors: Cheng X, Cheng B, Wan X, Lu W, Xie X
OBJECTIVE: To investigate clinical outcomes and fertility status of conservative treatment for epithelial ovarian carcinoma.
METHODS: The data of clinicopathological characteristics and follow-up were retrospectively collected and analyzed in 17 patients with early epithelial ovarian carcinoma who underwent...
Conservative surgery in patients with malignant ovarian germ cell tumours.
J Egypt Soc Parasitol. 2011 Dec;41(3):737-44
Authors: Al-Sayed MM, El-Sayed AA, El-Barbary TM, Hamad O
Conservative surgery with adjuvant chemotherapy has made the preservation of fertility even in patient with advanced disease. The increase in cure rate has shifted to research for the long term menstrual reproductive and gynecologic outcome in these patients. The current study is retrospective for 25...
Fertility sparing therapy for metastatic gestational trophoblastic disease in young patients.
Int J Gynaecol Obstet. 2012 Feb;116(2):170-1
Authors: Milenkovic V, Jeremic K, Lazovic B, Stefanovic A, Mirkovic L, Kadija S
PMID: 22093495 [PubMed - indexed for MEDLINE]
[The young cancer patient: psychosocial problems and concepts in rehabilitation].
Onkologie. 2011;34 Suppl 5:17-23
Authors: Beraldi A, Brathuhn S, Heussner P, König V, Lawrenz B
PMID: 21921663 [PubMed - indexed for MEDLINE]
A 10-year experience with treatment of high and standard risk Hodgkin disease: six cycles of tailored BEACOPP, with interim scintigraphy, are effective and female fertility is preserved.
Am J Hematol. 2012 Jan;87(1):32-6
Authors: Dann EJ, Blumenfeld Z, Bar-Shalom R, Avivi I, Ben-Shachar M, Goor O, Libster D, Gaitini D, Rowe JM, Epelbaum R
Therapy of Hodgkin lymphoma (HL) is designed to prolong survival and minimize toxicity. A total of 124 patients with newly diagnosed HL and...
Will imatinib compromise reproductive capacity?
Authors: Zamah AM, Mauro MJ, Druker BJ, Oktay K, Egorin MJ, Cedars MI, Rosen MP
Imatinib mesylate is the first in a family of highly effective, minimally toxic, targeted agents used widely to treat Philadelphia-positive leukemias and selected other cancers, leading to a steady rise in the prevalence of patients using such therapy. Because failure of therapy would require conventional gonadotoxic...
Fertility preservation in female cancer patients.
ISRN Obstet Gynecol. 2012;2012:807302
Authors: Kim CH, Jeon GH
With improved survival rates among cancer patients, fertility preservation is now being recognized as an issue of great importance. There are currently several methods of fertility preservation available in female cancer patients and the options and techniques via assisted reproduction and cryopreservation are increasing, but some are still experimental and...
Fertility preservation for patients with cancer.
Clin J Oncol Nurs. 2012 Apr 1;16(2):205-10
Authors: Kelvin JF, Kroon L, Ogle SK
A key concern for young patients with cancer and survivors is the desire to parent a child. With infertility being a well-established long-term effect of many oncologic regimens, patients who want to have children often become distressed when faced with the possibility of losing their fertility. Several organizations have recommended that oncology...
Select interviews from the 2011 San Antonio Breast Cancer Symposium (SABCS) and American Society of Hematology (ASH) Annual Meeting.
Oncology (Williston Park). 2011 Dec;25(14):1422-4, 1426
Authors: Osborne CK, Evens A
PMID: 22329194 [PubMed - indexed for MEDLINE]
Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer.
J Clin Oncol. 2012 Feb 10;30(5):533-8
Authors: Munster PN, Moore AP, Ismail-Khan R, Cox CE, Lacevic M, Gross-King M, Xu P, Carter WB, Minton SE
PURPOSE: Chemotherapy-induced amenorrhea is a serious concern for women undergoing cancer therapy. This prospective randomized trial evaluated the use of gonadotropin-...
Clinical Recommendation Radical Trachelectomy for Fertility Preservation in Patients With Early-Stage Cervical Cancer.
Int J Gynecol Cancer. 2012 Mar 6;
Authors: Schneider A, Erdemoglu E, Chiantera V, Reed N, Morice P, Rodolakis A, Denschlag D, Kesic V
ABSTRACT: Radical trachelectomy (RT) is a fertility-sparing procedure with the aim to provide adequate oncological safety to patients with cervical cancer while preserving their fertility. In the current review, indications,...
Effect of cryopreservation and transplantation on the expression of kit ligand and anti-Mullerian hormone in human ovarian tissue.
Hum Reprod. 2012 Feb 7;
Authors: David A, Van Langendonckt A, Gilliaux S, Dolmans MM, Donnez J, Amorim CA
BACKGROUNDAlthough cryopreservation and transplantation of ovarian tissue represent a promising alternative to safeguard fertility in cancer patients, low recovery rates of oocytes aspirated from antral follicles and a significant number of...