Improving survival rates for adolescents and young adults with cancer.
A chief concern affecting quality of life among young adult (YA) cancer survivors is fertility. Although discussions regarding the possibility of infertility and methods to decrease the risk are crucial at the time of diagnosis, many YAs don’t remember having adequate discussions regarding these topics before the initiation of their treatment. Embryo cryopreservation in women and sperm cryopreservation in men before cancer therapy remains to be the most effective ways in which fertility is preserved in the YA population. Although female and male gonadal tissue cryopreservation and transplantation remain experimental, such options are explored and continuously researched through programs such as the Oncofertility Consortium at Northwestern University.
Sources: Levine J, Canada A, Stern C. Fertility Preservation in Adolescents and Young Adults With Cancer. J Clin Oncol. 2010; 28:4831-4841.
Bleyer A, Barr R. Cancer in Young Adults 20 to 39 Years of Age: Overview. Semin Oncol. 2009; 36:194-206.
Clinical Recommendation Radical Trachelectomy for Fertility Preservation in Patients With Early-Stage Cervical Cancer.
Int J Gynecol Cancer. 2012 Mar 6;
Authors: Schneider A, Erdemoglu E, Chiantera V, Reed N, Morice P, Rodolakis A, Denschlag D, Kesic V
Abstract
ABSTRACT: Radical trachelectomy (RT) is a fertility-sparing procedure with the aim to provide adequate oncological safety to patients with cervical cancer while preserving their fertility. In the current review, indications,...
Effect of cryopreservation and transplantation on the expression of kit ligand and anti-Mullerian hormone in human ovarian tissue.
Hum Reprod. 2012 Feb 7;
Authors: David A, Van Langendonckt A, Gilliaux S, Dolmans MM, Donnez J, Amorim CA
Abstract
BACKGROUNDAlthough cryopreservation and transplantation of ovarian tissue represent a promising alternative to safeguard fertility in cancer patients, low recovery rates of oocytes aspirated from antral follicles and a significant number of...
Malignant ovarian germ cell tumours in gonadal Y chromosome mosaicism.
J Clin Pathol. 2011 Nov;64(11):973-6
Authors: Shahsiah R, Jahanbin B, Rabiei R, Ardalan FA, Sarhadi B, Izadi-Mood N
Abstract
AIMS: Previous studies have shown that two partially overlapping mechanisms are responsible for the development of malignant ovarian germ cell tumours (MOGCT): either spontaneous mutations, mostly in KIT gene, or the presence of Y chromosome material, in dysgenetic gonads. While unilateral...
Recommendations of the Fertility Task Force of the European Society of Gynecologic Oncology about the conservative management of ovarian malignant tumors.
Int J Gynecol Cancer. 2011 Jul;21(5):951-63
Authors: Morice P, Denschlag D, Rodolakis A, Reed N, Schneider A, Kesic V, Colombo N,
Abstract
In young patients with borderline ovarian tumor a conservative treatment approach does not seem to have a significant impact on survival, and the outcome regarding fertility is good in general....
Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants.
PLoS One. 2011;6(4):e19475
Authors: Soleimani R, Heytens E, Oktay K
Abstract
Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is...
Cancer therapy and fertility preservation.
J Assist Reprod Genet. 2011 Nov 15;
Authors:
PMID: 22083809 [PubMed - as supplied by publisher]
[Ovarian yolk sac tumour: general review].
Bull Cancer. 2011 Aug 1;98(8):963-75
Authors: Even C, Lhommé C, Duvillard P, Morice P, Balleyguier C, Pautier P, Troalen F, de La Motte Rouge T
Abstract
Ovarian yolk sac tumour (OYST) is a very rare malignancy arising most often in young women. Preoperative clinical, biological (alpha-foetoprotein) and radiological findings should help to establish the diagnosis of OYST, in order to propose adequate surgical treatment. The aim of surgery is...
Who Decides? Decision Making and Fertility Preservation in Teens With Cancer: A Review of the Literature.
J Adolesc Health. 2011 Oct;49(4):337-346
Authors: Quinn GP, Murphy D, Knapp C, Stearsman DK, Bradley-Klug KL, Sawczyn K, Clayman ML
Abstract
PURPOSE: The knowledge that cancer treatment may impair fertility in pediatric populations is an emerging aspect of quality of life in this population. However, decision making and use of fertility preservation (FP) among adolescent cancer...
Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise.
Aging (Albany NY). 2011 Aug 22;
Authors: Soleimani R, Heytens E, Darzynkiewicz Z, Oktay K
Abstract
The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety ofin vivo xenograft, and in vitro models to investigate the impact of chemotherapy-induced aging on the human...
Fertility-preserving measures for girls and young women with cancer.
Tidsskr Nor Laegeforen. 2011 Aug 9;131(15):1429-1432
Authors: Stensvold E, Magelssen H, Oskam IC
Background. Children and young adults with cancer may be rendered infertile as a result of their treatment. The purpose of this article is to provide an overview of fertility-preserving measures for girls and young women. Material and methods. The article is based on literature searches in the medical databases Medline, Pubmed and...
Multiple synchronous primary ovarian malignancies in a patient with a MLH-1 mutation: Impact on potential fertility preservation.
Gynecol Oncol. 2011 Jun 1;121(3):637-8
Authors: Phippen NT, Lowery WJ, Banks NB, Leath CA
PMID: 21353691 [PubMed - indexed for MEDLINE]
Multidisciplinary management of malignant ovarian germ cell tumours.
Gynecol Oncol. 2011 Jun 1;121(3):625-36
Authors: Parkinson CA, Hatcher HM, Earl HM, Ajithkumar TV
Malignant ovarian germ cell tumours (MOGCT) are rare cancers of young women. Limited prospective trials exist from which evidence-based management can be developed. This review summarizes the available literature concerning MOGT in order to provide the clinician with information relevant to their multidisciplinary management....
from patients, caregivers and medical professionals dealing with this disease and many other diseases
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