Globally, the incidence of sarcoma in young adults is approximately 2/100,000 persons with a greater incidence in males over females by a 2:1 ratio. Previous radiation and chemotherapy exposure before the age of 20, as well as exposure to certain chemical agents, has been linked to an increased risk in the development of sarcoma in the young adult population. Young adult sarcoma patients seem to do worse then their pediatric counterparts for a variety of reasons, one being the differences in the biology of their cancers. These differences in biology need to be accounted for when establishing treatment plans in this age group in determining pediatric- versus adult-based protocols.
Source: Soliman H, Ferrari A, Thomas D. Sarcoma in the Young Adult Population: An International View. Semin Oncol. 2009; 36:227-236.
Creating an adolescent and young adult cancer program: lessons learned from pediatric and adult oncology practice bases.
J Natl Compr Canc Netw. 2014 Oct;12(10):1409-15
Authors: Reed D, Block RG, Johnson R
Driven by reports of unmet clinical...
Use of appropriate initial treatment among adolescents and young adults with cancer.
J Natl Cancer Inst. 2014 Nov;106(11)
Authors: Potosky AL, Harlan LC, Albritton K, Cress RD, Friedman DL, Hamilton AS, Kato I, Keegan TH, Keel G, Schwartz SM, Seibel NL, Shnorhavorian M, West MM, Wu XC, AYA HOPE Study Collaborative Group
Adolescents and young adult cancer survivors: exercise habits, quality of life and physical activity preferences.
Support Care Cancer. 2014 Oct 8;
Authors: Murnane A, Gough K, Thompson K, Holland L, Conyers R
INTRODUCTION: Given the decades of survivorship for...
ENCCA WP17-WP7 consensus paper on teenagers and young adults (TYA) with bone sarcomas.
Ann Oncol. 2014 Jun 24;
Authors: Wilhelm M, Dirksen U, Bielack SS, Whelan JS, Lewis IJ, Jürgens H, Ferrari S, Sundby Hall K, Cleton-Jansen AM, Stark D
Teenagers and young adults (TYA) cancer contributes substantially to morbidity and...
Long-term cause-specific mortality in survivors of adolescent and young adult bone and soft tissue sarcoma: A population-based study of 28,844 patients.
Cancer. 2014 Apr 18;
Authors: Youn P, Milano MT, Constine LS, Travis LB
BACKGROUND: Despite improved cure rates for...
Medical care in adolescents and young adult cancer survivors: what are the biggest access-related barriers?
J Cancer Surviv. 2014 Jan 10;
Authors: Keegan TH, Tao L, Derouen MC, Wu XC, Prasad P, Lynch CF, Shnorhavorian M, Zebrack BJ, Chu R, Harlan LC, Smith AW, Parsons HM, AYA HOPE Study...
Trends in incidence of primary cutaneous malignancies in children, adolescents, and young adults: A population-based study.
Pediatr Blood Cancer. 2013 Oct 30;
Authors: Senerchia AA, Ribeiro KB, Galindo CR
BACKGROUND: Skin cancer incidence among young adults is rising;...
Cancer in adolescents and young adults, Kingston and St Andrew, Jamaica, 1988-2007.
West Indian Med J. 2013 Jan;62(1):21-7
Authors: Gibson TN, Hanchard B, Waugh N, McNaughton D
OBJECTIVE: To determine the distribution of malignancies in adolescents and young adults (AYA; 15 to 29 years) in Jamaica.
Racial and Ethnic Disparities in the Incidence and Trends of Soft Tissue Sarcoma Among Adolescents and Young Adults in the United States, 1995-2008.
J Adolesc Young Adult Oncol. 2013 Sep;2(3):89-94
Authors: Hsieh MC, Wu XC, Andrews PA, Chen VW
PURPOSE: The aim of this study was to examine racial/ethnic disparities in the...
Health-Related Quality of Life of Adolescent and Young Adult Patients With Cancer in the United States: The Adolescent and Young Adult Health Outcomes and Patient Experience Study.
J Clin Oncol. 2013 May 6;
Authors: Smith AW, Bellizzi KM, Keegan TH, Zebrack B, Chen VW, Neale AV,...
The Adolescent and Young Adult with Cancer: State of the Art - Bone Tumors.
Curr Oncol Rep. 2013 May 21;
Authors: Rainusso N, Wang LL, Yustein JT
Primary malignant bone tumors in the pediatric to young adult populations are relatively uncommon and account for...
Prognostic factors in adolescents and young adults (AYA) with high risk soft tissue sarcoma (STS) treated by adjuvant chemotherapy: A study based on pooled European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62771 and 62931.
Eur J Cancer. 2012 Sep 10;
Authors: Kasper B, Ouali M, van Glabbeke M, Blay JY, Bramwell VH, Woll PJ,...
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