Globally, the incidence of sarcoma in young adults is approximately 2/100,000 persons with a greater incidence in males over females by a 2:1 ratio. Previous radiation and chemotherapy exposure before the age of 20, as well as exposure to certain chemical agents, has been linked to an increased risk in the development of sarcoma in the young adult population. Young adult sarcoma patients seem to do worse then their pediatric counterparts for a variety of reasons, one being the differences in the biology of their cancers. These differences in biology need to be accounted for when establishing treatment plans in this age group in determining pediatric- versus adult-based protocols.
Source: Soliman H, Ferrari A, Thomas D. Sarcoma in the Young Adult Population: An International View. Semin Oncol. 2009; 36:227-236.
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Authors: Hughes RE, Holland LR, Zanino D, Link E, Michael N, Thompson KE
PURPOSE: While adolescent...
Marriage and fertility in long-term survivors of childhood, adolescent and young adult (AYA) high-grade sarcoma.
Int J Clin Oncol. 2016 Jan 20;
Authors: Yonemoto T, Takahashi M, Maru M, Tomioka A, Saito M, Araki Y, Tazaki M, Tsuchiya M, Iwata S, Kamoda H, Ishii T
Incidence and incidence trends of the most frequent cancers in adolescent and young adult Americans, including "nonmalignant/noninvasive" tumors.
Cancer. 2016 Feb 5;
Authors: Barr RD, Ries LA, Lewis DR, Harlan LC, Keegan TH, Pollock BH, Bleyer WA, US...
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults.
Cancer. 2016 Feb 5;
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Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma.
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Radiofrequency ablation of metastases from osteosarcoma in patients under 25 years: the SCFE experience.
Pediatr Hematol Oncol. 2015 Feb;32(1):41-9
Authors: Saumet L, Deschamps F, Marec-Berard P, Gaspar N, Corradini N, Petit P, Sirvent N, Brugières L
BACKGROUND: Radiofrequency ablation (RFA) has demonstrated its effectiveness in controlling metastases measuring less than 3 cm in...
Pediatric Melanoma and Atypical Melanocytic Neoplasms.
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Authors: Sreeraman Kumar R, Messina JL, Reed D, Navid F, Sondak VK
Melanoma is uncommon in the pediatric age range, but is increasing in frequency and often presents with atypical features compared to the classic ABCDE criteria common to adult melanoma cases. Moreover, many melanocytic neoplasms in childhood pose...
Mapping Adolescent Cancer Services: How Do Young People, Their Families, and Staff Describe Specialized Cancer Care in England?
Cancer Nurs. 2015 Oct 28;
Authors: Vindrola-Padros C, Taylor RM, Lea S, Hooker L, Pearce S, Whelan J, Gibson F
Who Treats Adolescents and Young Adults with Cancer? A Report from the AYA HOPE Study.
J Adolesc Young Adult Oncol. 2015 Sep 1;4(3):141-150
Authors: Parsons HM, Harlan LC, Schmidt S, Keegan TH, Lynch CF, Kent EE, Wu XC, Schwartz SM, Chu RL, Keel G, Smith AW, AYA HOPE Collaborative Group
Purpose: Physicians play a...
Osteosarcoma in patients younger than 12 years old without metastases have similar prognosis as adolescent and young adults.
Pediatr Blood Cancer. 2015 Jul;62(7):1209-13
Authors: Eleutério SJ, Senerchia AA, Almeida MT, Da Costa CM, Lustosa D, Calheiros LM, Barreto JH, Brunetto AL, Macedo CR, Petrilli AS...
The importance of assessing priorities of reproductive health concerns among adolescent and young adult patients with cancer.
Cancer. 2015 Aug 1;121(15):2529-36
Authors: Murphy D, Klosky JL, Reed DR, Termuhlen AM, Shannon SV, Quinn GP
Quality of life in adolescent and young adult cancer patients: a systematic review of the literature.
Patient Relat Outcome Meas. 2015;6:19-51
Authors: Quinn GP, Gonçalves V, Sehovic I, Bowman ML, Reed DR
INTRODUCTION: Adolescent and young adult (AYA...
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