Globally, the incidence of sarcoma in young adults is approximately 2/100,000 persons with a greater incidence in males over females by a 2:1 ratio. Previous radiation and chemotherapy exposure before the age of 20, as well as exposure to certain chemical agents, has been linked to an increased risk in the development of sarcoma in the young adult population. Young adult sarcoma patients seem to do worse then their pediatric counterparts for a variety of reasons, one being the differences in the biology of their cancers. These differences in biology need to be accounted for when establishing treatment plans in this age group in determining pediatric- versus adult-based protocols.
Source: Soliman H, Ferrari A, Thomas D. Sarcoma in the Young Adult Population: An International View. Semin Oncol. 2009; 36:227-236.
Docetaxel, bevacizumab, and gemcitabine for very high risk sarcomas in adolescents and young adults: A single-center experience.
Pediatr Blood Cancer. 2017 Apr;64(4):
Authors: Kuo C, Kent PM, Logan AD, Tamulonis KB, Dalton KL, Batus M, Fernandez K, Mcfall RE
The Benefits and Burdens of Cancer: A Prospective Longitudinal Cohort Study of Adolescents and Young Adults.
J Palliat Med. 2017 Jan 04;:
Authors: Straehla JP, Barton KS, Yi-Frazier JP, Wharton C, Baker KS, Bona K, Wolfe J, Rosenberg AR
BACKGROUND: Adolescents and early young adults (AYAs) with cancer are at high risk...
[Which approach of therapeutic education (TE) for adolescents and young adults with cancer? Experience from the TE working group of "Go-AJA"].
Bull Cancer. 2016 Dec;103(12):966-978
Authors: Corradini N, Dagorne L, Retailleau M, Rédini F, Sudour-Bonnange H, Gofti-Laroche L, Le...
Long-term survivors of childhood bone and soft tissue sarcomas are at risk of hospitalization.
Pediatr Blood Cancer. 2016 Dec 01;:
Authors: Gonzalez CD, Randall RL, Wright J, Spraker-Perlman H, Ying J, Sweeney C, Smith KR, Kirchhoff AC
BACKGROUND: Childhood cancer...
Rhabdomyosarcoma of the Breast in Adolescent and Young Adult (AYA) Women.
J Pediatr Hematol Oncol. 2016 Nov 22;
Authors: Audino AN, Setty BA, Yeager ND
Soft tissue sarcoma constitutes 8% of all tumors in adolescent and young adults (AYA), with rhabdomyosarcoma (RMS) accounting for 5.2% to 6.5% of the soft tissue sarcoma...
Disparity in Outcomes for Adolescent and Young Adult Patients Diagnosed With Pediatric Solid Tumors Across 4 Decades.
Am J Clin Oncol. 2016 Nov 10;
Authors: Chen I, Pasalic D, Fischer-Valuck B, Frangoul H, DeWees T, Shinohara ET, Perkins SM
Knowledge of Clinical Trial Availability and Reasons for Nonparticipation Among Adolescent and Young Adult Cancer Patients: A Population-based Study.
Am J Clin Oncol. 2016 Sep 15;
Authors: Shnorhavorian M, Doody DR, Chen VW, Hamilton AS, Kato I, Cress RD, West M, Wu XC, Keegan TH, Harlan LC,...
Detection of lymph node metastases in pediatric and adolescent/young adult sarcoma: Sentinel lymph node biopsy versus fludeoxyglucose positron emission tomography imaging-A prospective trial.
Cancer. 2016 Aug 26;
Authors: Wagner LM, Kremer N, Gelfand MJ, Sharp SE, Turpin BK, Nagarajan R, Tiao GM, Pressey...
Contraception: the Need for Expansion of Counsel in Adolescent and Young Adult (AYA) Cancer Care.
J Cancer Educ. 2016 Feb 15;
Authors: Fridgen O, Sehovic I, Bowman ML, Reed D, Tamargo C, Vadaparampil S, Quinn GP
Little is known about oncology provider...
[Management of febrile neutropenias in adolescents and young adults: Differences of practice between adult and pediatric units].
Bull Cancer. 2015 Nov;102(11):915-22
Authors: Penel-Page M, Normand C, Bertrand A, Levard A, Boyle H, Riberon C, Marec-Berard P
Prevalence and Intensity of Pain and Other Physical and Psychological Symptoms in Adolescents and Young Adults Diagnosed with Cancer on Referral to a Palliative Care Service.
J Adolesc Young Adult Oncol. 2015 Jun;4(2):70-5
Authors: Hughes RE, Holland LR, Zanino D, Link E, Michael N, Thompson KE
PURPOSE: While adolescent...
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