Melanoma is the 7th most common cancer in women and 6th most common cancer in men in the United States. The incidence of melanoma in California, a state with high sun-exposure, is the second most common of all cancers in young people under the age of 40. The 5-year overall survival for young people with malignant melanoma, presenting as a localized region, exceeds 90%. However, despite the lesser disease status, localized melanoma accounts for approximately 10% of all melanoma deaths in young people. Even worse, the 5-year overall survival for regional disease and distant metastatic disease is 65% and 15% respectively. Despite the fact that adolescents and young adults can tolerate high doses of treatment therapies they continue to be treated under less aggressive treatment adult-based guidelines. As we look forward it is important to continue to understand and learn more about the biology of melanomas in these different age groups especially through the role of immunotherapies as well as genetic lesions and progression markers of melanoma.
Source: Kirkwood J, Jukic D, Averbook B et al. Melanoma in Pediatric, Adolescent, and Young Adult Patients. Semin Oncol. 2009; 36:419-431.
Cancer Incidence and Survival in Adolescents and Young Adults in France, 2000-2008.
Pediatr Hematol Oncol. 2013 Jan 30;
Authors: Desandes E, Lacour B, Belot A, Molinie F, Delafosse P, Tretarre B, Velten M, Sauleau EA, Woronoff AS, Guizard AV, Ganry O, Bara S, Grosclaude P,...
Cancer in adolescents and young adults (15-29 years): A population-based study in the Netherlands 1989-2009.
Acta Oncol. 2012 Aug 30;
Authors: Aben KK, van Gaal C, van Gils NA, van der Graaf WT, Zielhuis GA
Background. Cancer among adolescents and young adults (AYAs; 15-29 years old) is relatively rare but its incidence is increasing worldwide. To define the extent and nature of the AYA patients, this population-based study was performed to explore trends in cancer incidence...
Immunotherapy for malignant melanoma--tracing Ariadne's thread through the labyrinth.
Eur J Cancer. 2009 Sep;45(13):2266-73
Authors: Grange JM, Krone B, Stanford JL
A working group (FEBIM) within the European Organisation for Research and...
from patients, caregivers and medical professionals dealing with this disease and many other diseases