Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
Therapeutic approaches to haematological malignancies in adolescents and young adults.
Br J Haematol. 2013 Sep 6;
Authors: Place AE, Frederick NN, Sallan SE
Tremendous strides have been made in improving the outcomes of haematological malignancies (HM) over the last...
The Adolescent and Young Adult with Cancer: State of the Art-- Acute Leukemias.
Curr Oncol Rep. 2013 Jun 12;
Authors: Gramatges MM, Rabin KR
Despite survival gains over the past several decades, adolescent and young adult (AYA) patients with both acute...
Impact of aberrant DNA methylation patterns including CYP1B1 methylation in adolescents and young adults with acute lymphocytic leukemia.
Am J Hematol. 2013 Jun 11;
Authors: Dinardo C, Gharibyan V, Yang H, Wei Y, Pierce S, Kantarjian H, Garcia-Manero G, Rytting M
The Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia.
Curr Hematol Malig Rep. 2013 Apr 5;
Authors: Lukenbill J, Advani AS
Adolescents and young adult (AYA) patients with acute lymphoblastic leukemia (ALL), 16-40 years of age, were...
Adolescents with acute lymphoblastic leukemia treated at pediatric versus adult hospitals.
Ann Oncol. 2012 Oct 28;
Authors: Pole JD, Alibhai SM, Ethier MC, Teuffel O, Portwine C, Zelcer S, Johnston DL, Silva M, Alexander S, Brandwein JM, Sung L
BackgroundThe objective was to compare 5-year overall survival (OS) between adolescent and young adult (AYA) patients (age 15-19) with acute lymphoblastic leukemia (ALL) treated at a pediatric versus an adult center.Patients and...
Survival Differences between Adolescent / Young Adults and Children with B-Precursor Acute Lymphoblastic Leukemia following Allogeneic Hematopoietic Cell Transplantation.
Biol Blood Marrow Transplant. 2012 Sep 5;
Authors: Burke MJ, Gossai N, Wagner JE, Smith AR, Bachanova V, Cao Q, Macmillan ML, Stefanski HS, Weisdorf DJ, Verneris MR
Risk adapted therapy has been the cornerstone of treatment for pediatric B-precursor acute lymphoblastic leukemia (B-ALL). Recently, age (≥13...
Acute lymphoblastic leukemia in young adults: which treatment?
Curr Opin Oncol. 2012 Jun 11;
Authors: McNeer JL, Raetz EA
PURPOSE OF REVIEW: Acute lymphoblastic leukemia (ALL) is the most common and one of the most curable malignancies in children; however, it presents unique challenges in adolescents and young adults (AYAs). The purpose of this review is to discuss factors that contribute to the outcome disparities in AYAs with ALL as well as approaches that can be taken to...
Impact of Cancer on Work and Education Among Adolescent and Young Adult Cancer Survivors.
J Clin Oncol. 2012 May 21;
Authors: Parsons HM, Harlan LC, Lynch CF, Hamilton AS, Wu XC, Kato I, Schwartz SM, Smith AW, Keel G, Keegan TH
PURPOSETo examine the impact of cancer on work and education in a sample of adolescent and young adult (AYA) patients with cancer. PATIENTS AND METHODSBy using the Adolescent and Young Adult Health Outcomes and Patient Experience Study (AYA HOPE)-a...
Cancer incidence and mortality trends in Australian adolescents and young adults, 1982-2007.
BMC Cancer. 2012 Apr 20;12(1):151
Authors: Haggar FA, Preen DB, Pereira G, Holman CD, Einarsdottir K
ABSTRACT: BACKGROUND: Increasing incidence and lack of survival improvement in adolescents and young adults (AYAs) with cancer have led to increased awareness of the cancer burden in this population. The objective of this study was to describe overall and type-specific cancer incidence...
Unmet adolescent and young adult cancer survivors information and service needs: a population-based cancer registry study.
J Cancer Surviv. 2012 Mar 29;
Authors: Keegan TH, Lichtensztajn DY, Kato I, Kent EE, Wu XC, West MM, Hamilton AS, Zebrack B, Bellizzi KM, Smith AW,
PURPOSE: We described unmet information and service needs of adolescent and young adult (AYA) cancer survivors (15-39 years of age) and identified sociodemographic and health-related factors associated with...
Adolescents and young adults with acute lymphoblastic leukemia have a better outcome when treated with pediatric-inspired regimens: Systematic review and meta-analysis.
Am J Hematol. 2012 Feb 8;
Authors: Ram R, Wolach O, Vidal L, Gafter-Gvili A, Shpilberg O, Raanani P
Survival of adults with acute lymphoblastic leukemia (ALL) is inferior to that of pediatric patients. Strategies to improve the outcome of adult population are warranted. This study aims to evaluate the efficacy...
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