Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
Overcoming Psychosocial and Developmental Barriers to Blood and Marrow Transplantation (BMT) in an Adolescent/Young Adult (AYA) Transgender Patient with Chronic Myelogenous Leukemia.
Pediatr Hematol Oncol. 2014 May 22;
Authors: Khazal S, Abdel-Azim H, Kapoor N, Mahadeo KM...
Reactive oxygen species regulate hematopoietic stem cell self renewal, migration, and development, as well as their bone marrow microenvironment.
Antioxid Redox Signal. 2014 Apr 24;
Authors: Ludin A, Gur-Cohen S, Golan K, Kaufmann KB, Itkin T, Medaglia C, Lu XJ, Ledergor G, Kollet O, Lapidot T
Significance: Blood forming...
Cancer Incidence and Survival among Adolescents and Young Adults in Korea.
PLoS One. 2014;9(5):e96088
Authors: Moon EK, Park HJ, Oh CM, Jung KW, Shin HY, Park BK, Won YJ
BACKGROUND: In Korea, cancer is the third leading cause of death among adolescents and...
Attitudes Toward Cancer Clinical Trial Participation in Young Adults with a History of Cancer and a Healthy College Student Sample: A Preliminary Investigation.
J Adolesc Young Adult Oncol. 2014 Mar 1;3(1):20-27
Authors: Grigsby TJ, Kent EE, Montoya MJ, Sender LS, Morris RA, Ziogas A, Anton-Culver H
Survival Analysis After Diagnosis With Malignancy of Egyptian Adolescent Patients: A Single-center Experience.
J Pediatr Hematol Oncol. 2014 Feb 10;
Authors: Tantawy AA, El Sherif NH, Ebeid FS, El-Desouky ED
BACKGROUND:: Adolescents with malignancy represent a...
Medical care in adolescents and young adult cancer survivors: what are the biggest access-related barriers?
J Cancer Surviv. 2014 Jan 10;
Authors: Keegan TH, Tao L, Derouen MC, Wu XC, Prasad P, Lynch CF, Shnorhavorian M, Zebrack BJ, Chu R, Harlan LC, Smith AW, Parsons HM, AYA HOPE Study...
Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: A Report from the Children's Oncology Group.
Cancer. 2013 Sep 19;
Authors: Canner J, Alonzo TA, Franklin J, Freyer DR, Gamis A, Gerbing RB, Lange BJ, Meshinchi S, Woods WG, Perentesis J, Horan...
Outcome of adolescents and young adults with acute myeloid leukemia treated on COG trials compared to CALGB and SWOG trials.
Cancer. 2013 Sep 19;
Authors: Woods WG, Franklin AR, Alonzo TA, Gerbing RB, Donohue KA, Othus M, Horan J, Appelbaum FR, Estey EH, Bloomfield CD, Larson RA
Therapeutic approaches to haematological malignancies in adolescents and young adults.
Br J Haematol. 2013 Sep 6;
Authors: Place AE, Frederick NN, Sallan SE
Tremendous strides have been made in improving the outcomes of haematological malignancies (HM) over the last...
The Adolescent and Young Adult with Cancer: State of the Art-- Acute Leukemias.
Curr Oncol Rep. 2013 Jun 12;
Authors: Gramatges MM, Rabin KR
Despite survival gains over the past several decades, adolescent and young adult (AYA) patients with both acute...
Impact of aberrant DNA methylation patterns including CYP1B1 methylation in adolescents and young adults with acute lymphocytic leukemia.
Am J Hematol. 2013 Jun 11;
Authors: Dinardo C, Gharibyan V, Yang H, Wei Y, Pierce S, Kantarjian H, Garcia-Manero G, Rytting M
The Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia.
Curr Hematol Malig Rep. 2013 Apr 5;
Authors: Lukenbill J, Advani AS
Adolescents and young adult (AYA) patients with acute lymphoblastic leukemia (ALL), 16-40 years of age, were...
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