Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
Adolescent and young adult patients with cancer: a milieu of unique features.
Nat Rev Clin Oncol. 2015 May 26;
Authors: Sender L, Zabokrtsky KB
Adolescent and young adult (AYA) patients with cancer are a unique category of patients who, depending on age at time...
How I Treat: Acute Lymphoblastic Leukemia in Older Adolescents and Young Adults (AYAs).
Blood. 2015 Mar 24;
Authors: Curran E, Stock W
At the intersection between children and older adults, the care of adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL) poses unique challenges and issues...
Adolescent and Young Adult (AYA) Oncology in the United States: A Specialty in Its Late Adolescence.
J Pediatr Hematol Oncol. 2015 Mar 6;
Authors: Shaw PH, Reed DR, Yeager N, Zebrack B, Castellino SM, Bleyer A
Over the last 30 years, it has become apparent...
Influence of Insurance and Marital Status on Outcomes of Adolescents and Young Adults With Acute Lymphoblastic Leukemia.
Clin Lymphoma Myeloma Leuk. 2014 Dec 12;
Authors: Fintel AE, Jamy O, Martin MG
BACKGROUND: Although outcomes for...
If You Did Not Document It, It Did Not Happen: Rates of Documentation of Discussion of Infertility Risk in Adolescent and Young Adult Oncology Patients' Medical Records.
J Oncol Pract. 2014 Dec 30;
Authors: Quinn GP, Block RG, Clayman ML, Kelvin J, Arvey SR, Lee JH, Reinecke J...
Adolescent and young adult cancer survival.
J Natl Cancer Inst Monogr. 2014 Nov;2014(49):228-35
Authors: Lewis DR, Seibel NL, Smith AW, Stedman MR
Adolescent and young adults (AYAs) face challenges in having their cancers...
Similar outcomes between adolescent/young adults and children with AML following allogeneic hematopoietic cell transplantation.
Bone Marrow Transplant. 2014 Feb;49(2):174-8
Authors: Burke MJ, Gossai N, Cao Q, Macmillan ML, Warlick E, Verneris MR
We recently reported...
Hematopoietic stem cell transplantation in adolescents and young adults.
Acta Haematol. 2014;132(3-4):313-25
Authors: Tewari P, Franklin AR, Tarek N, Askins MA, Mofield S, Kebriaei P
BACKGROUND: Adolescents and young adults (AYAs) are a very unique subset of our...
Use of appropriate initial treatment among adolescents and young adults with cancer.
J Natl Cancer Inst. 2014 Nov;106(11)
Authors: Potosky AL, Harlan LC, Albritton K, Cress RD, Friedman DL, Hamilton AS, Kato I, Keegan TH, Keel G, Schwartz SM, Seibel NL, Shnorhavorian M, West MM, Wu XC, AYA HOPE Study Collaborative Group
Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.
Blood Cancer J. 2014;4:e252
Authors: Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y...
Acute myeloid leukemia in adolescents and young adults: challenging aspects.
Acta Haematol. 2014;132(3-4):292-7
Authors: Ofran Y, Rowe JM
Treating adolescents and young adults (AYAs) diagnosed with cancer is a challenge. Acute myeloid leukemia (AML) which is...
Chronic myeloid leukemia in adolescents and young adults: patient characteristics, outcomes and review of the literature.
Acta Haematol. 2014;132(3-4):298-306
Authors: Pemmaraju N, Cortes J
Over the past two decades, many improvements have been made in the...
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