Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
If You Did Not Document It, It Did Not Happen: Rates of Documentation of Discussion of Infertility Risk in Adolescent and Young Adult Oncology Patients' Medical Records.
J Oncol Pract. 2014 Dec 30;
Authors: Quinn GP, Block RG, Clayman ML, Kelvin J, Arvey SR, Lee JH, Reinecke J...
Adolescent and young adult cancer survival.
J Natl Cancer Inst Monogr. 2014 Nov;2014(49):228-35
Authors: Lewis DR, Seibel NL, Smith AW, Stedman MR
Adolescent and young adults (AYAs) face challenges in having their cancers...
Hematopoietic stem cell transplantation in adolescents and young adults.
Acta Haematol. 2014;132(3-4):313-25
Authors: Tewari P, Franklin AR, Tarek N, Askins MA, Mofield S, Kebriaei P
BACKGROUND: Adolescents and young adults (AYAs) are a very unique subset of our...
Similar outcomes between adolescent/young adults and children with AML following allogeneic hematopoietic cell transplantation.
Bone Marrow Transplant. 2014 Feb;49(2):174-8
Authors: Burke MJ, Gossai N, Cao Q, Macmillan ML, Warlick E, Verneris MR
We recently reported...
Use of appropriate initial treatment among adolescents and young adults with cancer.
J Natl Cancer Inst. 2014 Nov;106(11)
Authors: Potosky AL, Harlan LC, Albritton K, Cress RD, Friedman DL, Hamilton AS, Kato I, Keegan TH, Keel G, Schwartz SM, Seibel NL, Shnorhavorian M, West MM, Wu XC, AYA HOPE Study Collaborative Group
Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.
Blood Cancer J. 2014;4:e252
Authors: Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y...
Acute myeloid leukemia in adolescents and young adults: challenging aspects.
Acta Haematol. 2014;132(3-4):292-7
Authors: Ofran Y, Rowe JM
Treating adolescents and young adults (AYAs) diagnosed with cancer is a challenge. Acute myeloid leukemia (AML) which is...
Chronic myeloid leukemia in adolescents and young adults: patient characteristics, outcomes and review of the literature.
Acta Haematol. 2014;132(3-4):298-306
Authors: Pemmaraju N, Cortes J
Over the past two decades, many improvements have been made in the...
Peer and Romantic Relationships among Adolescent and Young Adult Survivors of Childhood Hematological Cancer: A Review of Challenges and Positive Outcomes.
Acta Haematol. 2014;132(3-4):375-82
Authors: Foster RH, Stern M
This review focuses on peer and romantic...
Survivorship in adolescents and young adults.
Acta Haematol. 2014;132(3-4):383-90
Authors: Kishtagari A, Tavakkoli M, Park JH
In the USA, approximately 26,000 adolescents and young adults (AYAs) aged 15-29 years are diagnosed with cancer every year. The cure rate...
Acute lymphoblastic leukemia in adolescents and young adults.
Acta Haematol. 2014;132(3-4):264-73
Authors: Burke PW, Douer D
The cure rate of acute lymphoblastic leukemia (ALL) in children is 80%, compared to less than half in adults. A major proportion of this...
Treatment of adolescent and young adults with acute lymphoblastic leukemia.
Mediterr J Hematol Infect Dis. 2014;6(1):e2014052
Authors: Ribera JM, Ribera J, Genescà E
The primary objective of this review was to update and discuss the current concepts...
from patients, caregivers and medical professionals dealing with this disease and many other diseases