Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
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BACKGROUND: The authors describe the...
Acute lymphoblastic leukemia in adolescents and young adults.
Rinsho Ketsueki. 2015 Oct;56(10):2032-8
Authors: Hayakawa F
Treatments for acute lymphoblastic leukemia (ALL) have been developed, independently, by both pediatric and adult study groups. Adolescents...
Who Treats Adolescents and Young Adults with Cancer? A Report from the AYA HOPE Study.
J Adolesc Young Adult Oncol. 2015 Sep 1;4(3):141-150
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Purpose: Physicians play a...
Best Practices in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia: A Focus on Asparaginase.
J Adolesc Young Adult Oncol. 2015 Sep 1;4(3):118-128
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The inclusion of asparaginase in chemotherapy regimens...
Treatment of Acute Myeloid Leukemia in Adolescent and Young Adult Patients.
J Clin Med. 2015;4(3):441-59
Authors: Seval GC, Ozcan M
The objectives of this review were to discuss standard and investigational treatment strategies for adolescent and...
Unfavorable outcome of chronic myelogenous leukemia in adolescent and young adults treated with tyrosine kinase inhibitors.
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Outcome of adolescent patients with acute myeloid leukemia treated with pediatric protocols.
Int J Hematol. 2015 Jul 1;
Authors: Tomizawa D, Watanabe T, Hanada R, Horibe K, Horikoshi Y, Iwamoto S, Kinoshita A, Moritake H, Nakayama H, Shimada A, Taga T, Takahashi H, Tawa A, Terui K, Hori H, Kawano Y, Kikuta A, Manabe A, Adachi S
Treatment of pediatric lymphoma in Japan -The current status and the future plan.
Pediatr Int. 2015 Jun 11;
Authors: Kobayashi R, Sunami S, Mitsui T, Nakazawa A, Koga Y, Mori T, Tanaka F, Ueyama JI, Osumi T, Fukano R, Ohki K, Sekimizu M, Mori T, Lymphoma Committee, Japanese Pediatric Leukemia / Lymphoma Study Group
Adolescent and young adult patients with cancer: a milieu of unique features.
Nat Rev Clin Oncol. 2015 May 26;
Authors: Sender L, Zabokrtsky KB
Adolescent and young adult (AYA) patients with cancer are a unique category of patients who, depending on age at time...
How I Treat: Acute Lymphoblastic Leukemia in Older Adolescents and Young Adults (AYAs).
Blood. 2015 Mar 24;
Authors: Curran E, Stock W
At the intersection between children and older adults, the care of adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL) poses unique challenges and issues...
Adolescent and Young Adult (AYA) Oncology in the United States: A Specialty in Its Late Adolescence.
J Pediatr Hematol Oncol. 2015 Mar 6;
Authors: Shaw PH, Reed DR, Yeager N, Zebrack B, Castellino SM, Bleyer A
Over the last 30 years, it has become apparent...
Influence of Insurance and Marital Status on Outcomes of Adolescents and Young Adults With Acute Lymphoblastic Leukemia.
Clin Lymphoma Myeloma Leuk. 2014 Dec 12;
Authors: Fintel AE, Jamy O, Martin MG
BACKGROUND: Although outcomes for...
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