Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
Patient Characteristics and Outcomes in Adolescents and Young Adults (AYA) With Acute Myeloid Leukemia (AML).
Clin Lymphoma Myeloma Leuk. 2016 Jan 5;
Authors: Pemmaraju N, Kantarjian H, Ravandi F, Nogueras-Gonzalez GM, Huang X, O'Brien S, Wierda W, Garcia-Manero G, Thomas D,...
Providing Information About Late Effects During Routine Follow-Up Consultations Between Pediatric Oncologists and Adolescent Survivors: A Video-Based, Observational Study.
J Adolesc Young Adult Oncol. 2015;4(4):200-8
Authors: Mellblom AV, Korsvold L, Finset A, Loge J, Ruud E, Lie HC
PURPOSE: Information about late...
Psychological morbidities in adolescent and young adult blood cancer patients during curative-intent therapy and early survivorship.
Cancer. 2016 Jan 7;
Authors: Muffly LS, Hlubocky FJ, Khan N, Wroblewski K, Breitenbach K, Gomez J, McNeer JL, Stock W,...
An analysis of discrepancies between United Kingdom cancer research funding and societal burden and a comparison to previous and United States values.
Health Res Policy Syst. 2015;13:62
Increased risk of second malignant neoplasms in adolescents and young adults with cancer.
Cancer. 2015 Oct 6;
Authors: Lee JS, DuBois SG, Coccia PF, Bleyer A, Olin RL, Goldsby RE
BACKGROUND: The authors describe the...
Who Treats Adolescents and Young Adults with Cancer? A Report from the AYA HOPE Study.
J Adolesc Young Adult Oncol. 2015 Sep 1;4(3):141-150
Authors: Parsons HM, Harlan LC, Schmidt S, Keegan TH, Lynch CF, Kent EE, Wu XC, Schwartz SM, Chu RL, Keel G, Smith AW, AYA HOPE Collaborative Group
Purpose: Physicians play a...
Best Practices in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia: A Focus on Asparaginase.
J Adolesc Young Adult Oncol. 2015 Sep 1;4(3):118-128
Authors: Boissel N, Sender LS
The inclusion of asparaginase in chemotherapy regimens...
Acute lymphoblastic leukemia in adolescents and young adults.
Rinsho Ketsueki. 2015 Oct;56(10):2032-8
Authors: Hayakawa F
Treatments for acute lymphoblastic leukemia (ALL) have been developed, independently, by both pediatric and adult study groups. Adolescents...
Treatment of Acute Myeloid Leukemia in Adolescent and Young Adult Patients.
J Clin Med. 2015;4(3):441-59
Authors: Seval GC, Ozcan M
The objectives of this review were to discuss standard and investigational treatment strategies for adolescent and...
Unfavorable outcome of chronic myelogenous leukemia in adolescent and young adults treated with tyrosine kinase inhibitors.
Int J Hematol. 2015 Jul 18;
Authors: Sakurai M, Mori T, Karigane D, Tozawa K, Matsuki E, Shimizu T, Yokoyama K, Nakajima H, Kanda Y, Okamoto S
Outcome of adolescent patients with acute myeloid leukemia treated with pediatric protocols.
Int J Hematol. 2015 Jul 1;
Authors: Tomizawa D, Watanabe T, Hanada R, Horibe K, Horikoshi Y, Iwamoto S, Kinoshita A, Moritake H, Nakayama H, Shimada A, Taga T, Takahashi H, Tawa A, Terui K, Hori H, Kawano Y, Kikuta A, Manabe A, Adachi S
Treatment of pediatric lymphoma in Japan -The current status and the future plan.
Pediatr Int. 2015 Jun 11;
Authors: Kobayashi R, Sunami S, Mitsui T, Nakazawa A, Koga Y, Mori T, Tanaka F, Ueyama JI, Osumi T, Fukano R, Ohki K, Sekimizu M, Mori T, Lymphoma Committee, Japanese Pediatric Leukemia / Lymphoma Study Group
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