Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
Final results of a single institution experience with a pediatric-based regimen, the augmented berlin-frankfurt-münster (ABFM), in adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL), and comparison to the hyper-CVAD regimen.
Am J Hematol. 2016 May 14;
Authors: Rytting ME, Jabbour EJ...
Unmet Needs for Psychosocial Care in Hematologic Malignancies and Hematopoietic Cell Transplant.
Curr Hematol Malig Rep. 2016 Apr 25;
Authors: Barata A, Wood WA, Choi SW, Jim HS
Individuals diagnosed with hematologic malignancies experience significant unmet...
Adult acute lymphoblastic leukemia: current therapies and future perspectives.
Rinsho Ketsueki. 2016;57(3):230-7
Authors: Hayakawa F
There was no significant improvement in the treatment of adult acute lymphoblastic leukemia (ALL) in the 1ast two decades of the...
ReCAP: Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program.
J Oncol Pract. 2016 Mar 29;
Authors: Roth ME, O'Mara AM, Seibel NL, Dickens DS, Langevin AM, Pollock BH, Freyer DR, Roth ME, O'Mara AM, Seibel NL,...
Cardiovascular Disease Risk Profiles in Survivors of Adolescent and Young Adult (AYA) Cancer: The Kaiser Permanente AYA Cancer Survivors Study.
J Clin Oncol. 2016 Mar 7;
Authors: Chao C, Xu L, Bhatia S, Cooper R, Brar S, Wong FL, Armenian SH
Social Media and the Adolescent and Young Adult (AYA) Patient with Cancer.
Curr Hematol Malig Rep. 2016 Feb 18;
Authors: Perales MA, Drake EK, Pemmaraju N, Wood WA
Over 70,000 adolescent and young adults (AYA) aged 15 to 39 years are diagnosed with cancer each...
Is the Adolescent and Young Adult Cancer Survivor at Risk for Late Effects? It Depends on Where You Look.
J Adolesc Young Adult Oncol. 2016 Feb 17;
Authors: Barthel EM, Spencer K, Banco D, Kiernan E, Parsons S
PURPOSE: The adolescent and young adult (AYA) population is a growing group of survivors, exceeding more than...
Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes.
Oncotarget. 2016 Feb 12;
Authors: Messina M, Chiaretti S, Wang J, Fedullo AL, Peragine N, Gianfelici V, Piciocchi A, Brugnoletti F, Di Giacomo F,...
[Retrospective Analysis of the Impact of Treatment on Prognosis in 44 Adolescents and Young Adult Patients with Acute Lymphoblastic Leukemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Feb;24(1):14-8
Authors: Chen XP, Lv N, Li YH, Jing Y, Yu L
OBJECTIVE: To study the clinical characteristics and the impact of treatment on...
Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma.
Cancer. 2016 Feb 5;
Authors: Tricoli JV, Blair DG, Anders CK, Bleyer A, Boardman LA, Khan J...
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults.
Cancer. 2016 Feb 5;
Authors: Keegan TH, Ries LA, Barr RD, Geiger AM, Dahlke DV, Pollock BH, Bleyer A, National Cancer...
Incidence and incidence trends of the most frequent cancers in adolescent and young adult Americans, including "nonmalignant/noninvasive" tumors.
Cancer. 2016 Feb 5;
Authors: Barr RD, Ries LA, Lewis DR, Harlan LC, Keegan TH, Pollock BH, Bleyer WA, US...
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