Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010.
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Racial and ethnic disparities in the survival of adolescents and young adults with acute myeloid leukemia: a retrospective study using the US National Cancer Data Base.
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Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation.
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Outcome of Adolescents and Young Adults Compared With Pediatric Patients With Acute Myeloid and Promyelocytic Leukemia.
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BACKGROUND: Studies on the...
Knowledge of Clinical Trial Availability and Reasons for Nonparticipation Among Adolescent and Young Adult Cancer Patients: A Population-based Study.
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Authors: Shnorhavorian M, Doody DR, Chen VW, Hamilton AS, Kato I, Cress RD, West M, Wu XC, Keegan TH, Harlan LC,...
Epidemiology of Adolescents and Young Adults with Cancer in Europe.
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To design the services for adolescents and young adults (AYAs) with cancer, we need to understand the patterns of disease and the other...
Prog Tumor Res. 2016;43:87-100
Authors: Juliusson G, Hough R
Leukemias are a group of life threatening malignant disorders of the blood and bone marrow. In the adolescent and young adult (AYA) population, the acute leukemias are most prevalent, with...
Adoption of pediatric-inspired acute lymphoblastic leukemia regimens by adult oncologists treating adolescents and young adults: A population-based study.
Cancer. 2016 Sep 13;
Authors: Muffly L, Lichtensztajn D, Shiraz P, Abrahão R, McNeer J, Stock W, Keegan T, Gomez SL
Myelodysplastic Syndromes in Adolescent Young Adults: One Institution's Experience.
Clin Lymphoma Myeloma Leuk. 2016 Aug;16 Suppl:S53-6
Authors: Grabska J, Shah B, Reed D, Al Ali N, Padron E, Ramadan H, Lancet J, List A, Komrokji R
L-asparaginase in the treatment of patients with acute lymphoblastic leukemia.
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Authors: Egler RA, Ahuja SP, Matloub Y
Acute lymphoblastic leukemia (ALL) is a hematologic malignancy that predominantly...
Racial disparities in the survival of American children, adolescents, and young adults with acute lymphoblastic leukemia, acute myelogenous leukemia, and Hodgkin lymphoma.
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