Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
Outcome of Adolescents and Young Adults Compared With Pediatric Patients With Acute Myeloid and Promyelocytic Leukemia.
Clin Lymphoma Myeloma Leuk. 2016 Sep 17;:
Authors: Nasir SS, Giri S, Nunnery S, Martin MG
BACKGROUND: Studies on the...
Epidemiology of Adolescents and Young Adults with Cancer in Europe.
Prog Tumor Res. 2016;43:1-15
Authors: Desandes E, Stark DP
To design the services for adolescents and young adults (AYAs) with cancer, we need to understand the patterns of disease and the other...
Knowledge of Clinical Trial Availability and Reasons for Nonparticipation Among Adolescent and Young Adult Cancer Patients: A Population-based Study.
Am J Clin Oncol. 2016 Sep 15;
Authors: Shnorhavorian M, Doody DR, Chen VW, Hamilton AS, Kato I, Cress RD, West M, Wu XC, Keegan TH, Harlan LC,...
Adoption of pediatric-inspired acute lymphoblastic leukemia regimens by adult oncologists treating adolescents and young adults: A population-based study.
Cancer. 2016 Sep 13;
Authors: Muffly L, Lichtensztajn D, Shiraz P, Abrahão R, McNeer J, Stock W, Keegan T, Gomez SL
Prog Tumor Res. 2016;43:87-100
Authors: Juliusson G, Hough R
Leukemias are a group of life threatening malignant disorders of the blood and bone marrow. In the adolescent and young adult (AYA) population, the acute leukemias are most prevalent, with...
Myelodysplastic Syndromes in Adolescent Young Adults: One Institution's Experience.
Clin Lymphoma Myeloma Leuk. 2016 Aug;16 Suppl:S53-6
Authors: Grabska J, Shah B, Reed D, Al Ali N, Padron E, Ramadan H, Lancet J, List A, Komrokji R
L-asparaginase in the treatment of patients with acute lymphoblastic leukemia.
J Pharmacol Pharmacother. 2016 Apr-Jun;7(2):62-71
Authors: Egler RA, Ahuja SP, Matloub Y
Acute lymphoblastic leukemia (ALL) is a hematologic malignancy that predominantly...
Racial disparities in the survival of American children, adolescents, and young adults with acute lymphoblastic leukemia, acute myelogenous leukemia, and Hodgkin lymphoma.
Cancer. 2016 Jun 10;
Authors: Kahn JM, Keegan TH, Tao L, Abrahão R, Bleyer A, Viny AD
Final results of a single institution experience with a pediatric-based regimen, the augmented berlin-frankfurt-münster (ABFM), in adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL), and comparison to the hyper-CVAD regimen.
Am J Hematol. 2016 May 14;
Authors: Rytting ME, Jabbour EJ...
Adult acute lymphoblastic leukemia: current therapies and future perspectives.
Rinsho Ketsueki. 2016;57(3):230-7
Authors: Hayakawa F
There was no significant improvement in the treatment of adult acute lymphoblastic leukemia (ALL) in the 1ast two decades of the...
Unmet Needs for Psychosocial Care in Hematologic Malignancies and Hematopoietic Cell Transplant.
Curr Hematol Malig Rep. 2016 Apr 25;
Authors: Barata A, Wood WA, Choi SW, Jim HS
Individuals diagnosed with hematologic malignancies experience significant unmet...
ReCAP: Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program.
J Oncol Pract. 2016 Mar 29;
Authors: Roth ME, O'Mara AM, Seibel NL, Dickens DS, Langevin AM, Pollock BH, Freyer DR, Roth ME, O'Mara AM, Seibel NL,...
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