Breast cancer by the age of 40 accounts for more than 40% of all cancers diagnosed among women. Breast cancer survival rates in women under 40 years of age are lower than those seen in older women regardless of disease staging or subtype. When developing treatment plans for young women diagnosed with breast cancer it is important to address fertility issues such as infertility and pregnancy as well as a deeper understanding of the psychosocial issues the patient may be experiencing. Breast development, conservation and reconstruction are also important issues to be considered as they pertain to body image and overall wellbeing. Breast cancer diagnosed at a younger age can present as more biologically aggressive and have worse outcomes than those diagnosed at a later age, which demonstrates the need for clinical trials tailored towards better understanding this age group’s unique biology and increasing overall survival for this young population.
Source: Anders C, Johnson R, Litton J, et al. Breast Cancer Before Age 40 Years. Semin Oncol. 2009; 36:237-249.
A Population-Based Observational Study of First-Course Treatment and Survival for Adolescent and Young Adult Females with Breast Cancer.
J Adolesc Young Adult Oncol. 2013 Sep;2(3):95-103
Authors: Derouen MC, Gomez SL, Press DJ, Tao L, Kurian AW, Keegan TH
PURPOSE: Young age at breast cancer diagnosis is associated with...
Impact of breast cancer subtypes on three-year survival among adolescent and young adult women.
Breast Cancer Res. 2013 Oct 16;15(5):R95
Authors: Keegan TH, Press DJ, Tao L, Derouen MC, Kurian AW, Clarke CA, Gomez SL
INTRODUCTION: Young women have poorer...
Breast cancer in adolescents and young adults: a review with a focus on biology.
J Natl Compr Canc Netw. 2013 Sep 1;11(9):1060-9
Authors: Tichy JR, Lim E, Anders CK
Breast cancer is a substantial contributor to adolescent and young adult (AYA...
The Adolescent and Young Adult With Cancer: State of the Art-Epithelial Cancer.
Curr Oncol Rep. 2013 Jun 11;
Authors: Ferreira CG, de Melo AC, Nogueira-Rodrigues A
The adolescent and young adult (AYA) is defined as a patient of 15 to 39 years of age at initial...
Survival among adolescents and young adults with cancer in Germany and the United States: An international comparison.
Int J Cancer. 2013 Apr 24;
Authors: Gondos A, Hiripi E, Holleczek B, Luttmann S, Eberle A, Brenner H
Serious concern arose in the scientific literature...
Delay in Surgical Treatment and Survival After Breast Cancer Diagnosis in Young Women by Race/Ethnicity.
JAMA Surg. 2013 Apr 24;:1-8
Authors: Smith EC, Ziogas A, Anton-Culver H
IMPORTANCE Breast cancer in women between the ages of...
Physical and mental health status of female adolescent/young adult survivors of breast and gynecological cancer: a national, population-based, case-control study.
Support Care Cancer. 2013 Jan 10;
Authors: Phillips-Salimi CR, Andrykowski MA
Cancer in adolescents and young adults (15-29 years): A population-based study in the Netherlands 1989-2009.
Acta Oncol. 2012 Aug 30;
Authors: Aben KK, van Gaal C, van Gils NA, van der Graaf WT, Zielhuis GA
Background. Cancer among adolescents and young adults (AYAs; 15-29 years old) is relatively rare but its incidence is increasing worldwide. To define the extent and nature of the AYA patients, this population-based study was performed to explore trends in cancer incidence...
Cancer incidence and mortality trends in Australian adolescents and young adults, 1982-2007.
BMC Cancer. 2012 Apr 20;12(1):151
Authors: Haggar FA, Preen DB, Pereira G, Holman CD, Einarsdottir K
ABSTRACT: BACKGROUND: Increasing incidence and lack of survival improvement in adolescents and young adults (AYAs) with cancer have led to increased awareness of the cancer burden in this population. The objective of this study was to describe overall and type-specific cancer incidence...
Occurrence of breast cancer subtypes in adolescent and young adult women.
Breast Cancer Res. 2012 Mar 27;14(2):R55
Authors: Keegan TH, Derouen MC, Press DJ, Kurian AW, Clarke CA
ABSTRACT: INTRODUCTION: Breast cancers are increasingly recognized as heterogeneous based on expression of receptors for estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2). Triple-negative tumors (ER-/PR-/HER2-) have been reported as more common among younger women,...
Running from her past: a case of rapidly progressive dyspnea on exertion.
Circulation. 2011 Nov 22;124(21):2355-61
Authors: McCabe JM, Bhave PD, McGlothlin D, Teerlink JR
PMID: 22105198 [PubMed - indexed for MEDLINE]
Fatigue, pain, and functional status during outpatient chemotherapy.
Oncol Nurs Forum. 2010 Mar;37(2):E114-23
Authors: Siefert ML
To examine the relationship of fatigue and pain with functional status and the pattern of the two symptoms' occurrence over time in individuals with cancer who were receiving outpatient chemotherapy. The aims were to describe the levels of fatigue and pain with functional status and the inter-relationships with each other and with demographic and clinical variables over...
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